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The HZI is on the leap to new antiviral agents To let the citizen scientists know what happens next with… Some of these show promising properties and are therefore already being studied in more detail. From these samples, just as many new myxobacteria and several new natural products have already been identified. So far, citizen scientists have provided HIPS with over 700 soil samples from Saarland and other areas of Germany. The threat posed by this germ is exacerbated by the fact that variants are increasingly becoming…
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aeruginosa poses a particular threat to cystic fibrosis and Covid-19 patients during artificial respiration. The hospital germ Pseudomonas aeruginosa causes a variety of infectious diseases: from pneumonia to wound, eye and urinary tract infections to sepsis. A successful implementation of translational research is thus achieved.
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The combined research activities and experiences of the scientists at HIPS, HZI and further regional cooperation institutes in drug development allow for the complete coverage in drug development from drug discovery to clinical phase IIa studies. This greatly enhances the chance of identifying and utilizing novel natural products, and accelerates their advancement to clinical studies. The complementary expertise allows concerted and synchronous approaches to the discovery and mining of novel producers of potential drugs, their rational improvement and bioprofiling, as well as their optimal formulation. The combination of the knowledge on infectious diseases and the pharmaceutical research of HZI and HIPS takes a unique position in Germany and Europe, especially regarding the development of anti-infectives. The range of scientific activities at HIPS comprises genetic and genome-analytic methods for optimizing natural product producers and lead compounds as well as methodologies to improve the transportation of pharmaceutical agents to their target. AMEG develops new tools for actinomycete genetics and applies these tools in the genetics of natural products producers. In January 2011, Andriy Luzhetskyy has established the Junior Research Group AMEG (Actinobacteria Metabolic Engineering Group) within MINS. Research at HIPS focuses on the development of new anti-infectives: Rolf Müller focuses on microbial active agents, primarily from myxobacteria (Department MINS, Microbial Natural Products), Anna Hirschs’s research is specialized in pharmaceutical and medicinal chemistry (Department DDOP Drug Design and Optimization), while Claus-Michael Lehr is examining the targeted transport of drugs to the disease’s source (Department DDEL Drug Delivery). Focus on the development of new anti-infectives Professor Rolf Müller, besides being the director of the institute, leads of one of the departments, the other two are headed by Prof. HIPS consists of three departments and in the near future three junior research groups. It is by this foundation that the Helmholtz Association, which is the largest research organisation in Germany, now becomes represented in the Saarland, too. The institute is a branch of HZI and the first public research institute in Germany, that is explicitly devoted to the pharmaceutical sciences.